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Catanionic vesicular systems
Repová, Romana ; Krouská, Jitka (referee) ; Mravec, Filip (advisor)
This bachelor thesis deals with catanionic vesicles. The aim of the study was to prepare and characterize these systems. The catanionic vesicles are composed of cationic (CTAB, CTAC, TTAB, DTAB) and anionic surfactants (SDS). The physical stability of the vesicles was enhanced with the addition of cationic surfactant DODAC.The catanionic vesicles were characterized by the measurement of the dynamic light scattering, zeta potencial and fluorescence correlation spectroscopy. The size and stability of the system were determined using dynamic light scattering. Difussion coefficient of the system was analyzed using fluorescence correlation spectroscopy.
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Study of membrane properties of catanionic vesicles from new SEPT-DS amphiphilic ion pairs
Vajcíková, Katarína ; Krouská, Jitka (referee) ; Mravec, Filip (advisor)
This work describes the possibility of determining the membrane properties of vesicular systems formed by ion pair amphiphile (IPAs), which were prepared by mixing positively and negatively charged surfactants, namely the positively charged surfactant carbethopendecinium bromide (Septonex) and negatively charged surfactant sodium dodecyl sulphate with the addition of dioctadecyldimethylammonium chloride and cholesterol for stability enhancement. Such systems are potential drug carriers and hence their careful characterization is very important for further research. In this work, the possibilities of studying the membrane properties of such systems using spectrometric methods, namely fluorescence anisotropy and generalized polarization, by which the fluidity and solvation of the bilayer membrane were detected as a function of the amount of added cholesterol and the change in temperature, are described. The size and stability of the prepared vesicular systems formed from the new amphiphilic pairs were investigated by dynamic and electrophoretic light scattering, and finally, the phase transition temperature was detected using differential scanning calorimetry method.
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Catanionic vesicular systems
Repová, Romana ; Krouská, Jitka (referee) ; Mravec, Filip (advisor)
This bachelor thesis deals with catanionic vesicles. The aim of the study was to prepare and characterize these systems. The catanionic vesicles are composed of cationic (CTAB, CTAC, TTAB, DTAB) and anionic surfactants (SDS). The physical stability of the vesicles was enhanced with the addition of cationic surfactant DODAC.The catanionic vesicles were characterized by the measurement of the dynamic light scattering, zeta potencial and fluorescence correlation spectroscopy. The size and stability of the system were determined using dynamic light scattering. Difussion coefficient of the system was analyzed using fluorescence correlation spectroscopy.
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